基本信息
姓 名:郑秉得
所在单位:manbetx
化工与制药工程系
职 称:讲师
电 话:13295978160
电子信箱:bingd.zheng@manbetx88.org
通讯地址:福建省厦门市集美大道668号
研究室:泛华科技大楼B712
研究领域
研究方向:功能染料分子构建具有疾病诊疗与成像检测功能的光热剂/光敏剂的开发,海洋生物资源综合利用,海洋精细化工
教育背景
2015.09-2020.12 福州大学 生物化工专业 工学博士(推免生,硕博连读)
2011.09-2015.06 福建农林大学 制药工程专业 工学学士
工作经历
2021.05-至今 manbetx
课程教学
研究生:高等制药工艺学、现代制剂工程学(硕士生)
本科生:药物化学实验、化工与制药创新实验、化工原理实验、生产实习、药物合成
个人荣誉
福建省高层次人才
科研项目
1.国家自然科学基金委员会,面上项目,22078066,酞菁纳米聚集体的调控、光动力免疫效应与抗肿瘤转移研究, 2021-01至2024-12,64万元,在研,参与
2.国家自然科学基金委员会,联合基金项目,U1705282,新型光/声动力纳米药物的构建、双模态成像与协同抗肿瘤效应,2018-01至2021-12,204万元,在研,参与
3.华侨大学,高层次人才科研启动项目,21BS107,功能光敏剂的合成与性质研究,2021-06至2024-06,12万元,在研,主持
4.福州大学,福州大学化学一流学科博士研究生科技创新基金项目,新型酞菁脂质体纳米药物的制备与性能评价,2018-10至2020-05,5万元,已结题,主持
学术成果(信息更新至2022.05.12)
1. B.D. Zheng*, J. Ye, Y.C. Yang, Y.Y. Huang, M.T. Xiao*, Self-healing polysaccharide-based injectable hydrogels with antibacterial activity for wound healing, Carbohyd Polym, 275 (2022) 118770.(IF:9.381)
2. S.L. Cai, N. Pan, M. Xu, Y.C. Su, K. Qiao, B. Chen, B.D. Zheng*, M.T. Xiao*, Z.Y. Liu*, ACE Inhibitory Peptide from Skin Collagen Hydrolysate of Takifugu bimaculatus as Potential for Protecting HUVECs Injury, Mar Drugs, 19 (2021) 655.(IF:5.118)
3. B.D. Zheng, Q.X. He, X.S. Li*, J. Yoon*, J.D. Huang*, Phthalocyanines as contrast agents for photothermal therapy, Coordin Chem Rev, 426 (2021) 213548.(IF:22.315)
4. B.D. Zheng, Z.L. Huang, L.L. Lv, W.L. Lan, J.Q. Hu, X.S. Li, B.Y. Zheng, M.R. Ke*, J.D. Huang*, A pH-sensitive nanoagent self-assembled from a highly negatively-charged phthalocyanine with excellent biosafety for photothermal therapy, J Mater Chem B, 9 (2021) 2845-2853. (IF:6.331)
5. B.D. Zheng*, J. Ye, X.Q. Zhang, N. Zhang, M.T. Xiao*, Recent advances in supramolecular activatable phthalocyanine-based photosensitizers for anti-cancer therapy, Coordin Chem Rev, 447 (2021) 214155.(IF:22.315)
6. B.D. Zheng*, J. Ye, Y.Y. Huang, M.T. Xiao*, Phthalocyanine-based photoacoustic contrast agents for imaging and theranostics, Biomater Sci-Uk, 9 (2021) 7811-7825. (IF:6.843)
7. B.Y. Zheng, S.Z. Li, B.D. Zheng, J.W. Ying, Q.Y. Hu, X.H. Peng, X.S. Li, M.R. Ke, J.D. Huang*, Phthalocyanine-based photosensitizers combined with anti-PD-L1 for highly efficient photodynamic immunotherapy, Dyes Pigments, 185 (2021) 108907. (IF:4.889)
8. B.D. Zheng, S.L. Li, Z.L. Huang, L. Zhang, H. Liu, B.Y. Zheng, M.R. Ke, J.D. Huang*, A non-aggregated zinc(II) phthalocyanine with hexadeca cations for antitumor and antibacterial photodynamic therapies, J Photoch Photobio B, 213 (2020) 112086. (IF:6.252)
9. X. Li, B.D. Zheng, X.H. Peng, S.Z. Li, J.W. Ying, Y.Y. Zhao, J.D. Huang*, J. Yoon*, Phthalocyanines as medicinal photosensitizers: Developments in the last five years, Coordin Chem Rev, 379 (2019) 147-160. (IF:22.315)
10. X.S. Li, X.H. Peng, B.D. Zheng, J.L. Tang, Y.Y. Zhao, B.Y. Zheng, M.R. Ke, J.D. Huang*, New application of phthalocyanine molecules: from photodynamic therapy to photothermal therapy by means of structural regulation rather than formation of aggregates, Chem Sci, 9 (2018) 2098-2104.(IF:9.825)
11. B.D. Zheng, Y.Y. Zhao, H.C. Li, B.Y. Zheng, M.R. Ke, J.D. Huang*, Activatable Photodynamic Anticancer Photosensitizers, Prog Chem, 30 (2018) 1403-1414. (IF:1.172)
12. X.H. Peng, S.F. Chen, B.Y. Zheng, B.D. Zheng, Q.F. Zheng, X.S. Li, M.R. Ke, J.D. Huang*, Comparison between amine-terminated phthalocyanines and their chlorambucil conjugates: Synthesis, spectroscopic properties, and in vitro anticancer activity, Tetrahedron, 73 (2017) 378-384. (IF:2.457)
13. Z.T. Wang, Y.C. Yang, S.S. Zeng, M. Arowo, X.Q. Zhang, B.D. Zheng, N. Zhang, J. Ye, M.T. Xiao, Treatment of organic wastewater by ozone in a continuous rotating solid foam stirrer tank, Chem. Eng. Process, 147 (2022) 1088866. (IF:4.237)
14. 袁晓露,李宝霞,黄雅燕,杨宇成,叶静,张娜,张学勤,郑秉得*,肖美添*,海藻酸钠微囊的制备及应用进展,化工进展,41 (2022) 3103-3112. (EI)
授权专利
1. 黄剑东; 彭小慧; 郑秉得; 取代酞菁铜及其在光热材料和光热治疗领域的应用, 2020-4-7, 中国, ZL 2017 1 1100018.9
2. 黄剑东; 郑秉得; 柯美荣; 郑碧远; 十六铵基修饰的酞菁及其制备方法与作为光动力药物的应用, 2021-6-1, 中国, ZL 2020 1 1112741.0
学术会议
1. 郑秉得; 通过结构调控:具有光热抗癌效应的酞菁分子, 2020年福建省化工、环境与生物类研究生论坛, 福建厦门, 2020-12-13至2020-12-13 (会议报告)
2. 郑秉得; 彭小慧; 马新月; 李兴淑; 郑碧远; 柯美荣; 黄剑东; 具有光热抗癌效应的酞菁分子:通过结构调控策略, 2019年中国药物化学学术会议暨中欧药物化学研讨会, 四川成都, 2019-08-15至2019-08-18 (会议报告)
3. 彭小慧; 陈少芳; 郑巧凤; 郑秉得; 郑碧远; 柯美荣; 黄剑东; 光/化疗偶联物硅酞菁-苯丁酸氮芥的合成与光动力活性, 中国化学会第三届卟啉与酞菁学术讨论会, 福建福州, 2015-12-18至2015-12-20 (会议报告)